5/17/2023 0 Comments Utterly smooth![]() It is very important to tell your care team at the first sign of HFS. These blisters become very painful and can interfere with daily activities. ![]() If there is no change in the treatment, the hands and/or feet can blister, which can then become infected. HFS can start as a feeling of tingling or numbness in the palms and/or soles, which leads to swelling, redness, peeling skin, and tenderness or pain. Chemotherapy drugs known to cause HFS include: capecitabine (Xeloda®), fluorouracil (5-FU), liposomal doxorubicin (Doxil®), doxorubicin (Adriamycin®), cytarabine (Ara-c®), sunitinib (Sutent®) and sorafenib (Nexavar®). It may also be referred to as acral erythema, palmar plantar erythema (PPE), or Burgdorf reaction. Hand-foot syndrome (HFS) is a skin reaction on the palms of the hands and/or the soles of the feet as a result of certain chemotherapy agents.
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